Skin manifestations of primary immune deficiency diseases

Primary immune deficiency diseases (PIDDs) are a group of severe genetically determined caused by disorder the immunity links: humoral and cell-mediated links, phagocytosis, complement system. PIDDs characterized atypical recurrent infections, as well autoimmune oncological processes. In case clinical symptoms, skin manifestations in allow to suspect presence congenital disorders immunity. There is technique laboratory diagnostics PIDDs, that determines decrease number T- B-lymphocytes based on measuring levels TREC (T-cell Receptor Excision Circle) KREC (Kappa-deleting Recombination Circle), which by-products recombination B-cell receptor genes. can be assessed using reagent kit for quantifying DNA PCR real time. The analysis conducted both whole blood obtained from dried stains collected during national newborn screening program. Today, quantitative cards becoming method choice PIDDs. inclusion diagnosis federal program will detecting system before their manifestations, apply modern treatment protocols, reduce disability ensure high patient survival. KEYWORDS: TREC, KREC, screening, PCR, immunity, early diagnosis. FOR CITATION: Churyukina E.V., Kudlay D.A. Skin primary diseases. Russian Medical Inquiry. 2022;6(2):98–104 (in Russ.). DOI: 10.32364/2587-6821-2022-6-2-98-104